منابع مشابه
Single-molecule spectroscopy and imaging of biomolecules in living cells.
The number of reports per year on single-molecule imaging experiments has grown roughly exponentially since the first successful efforts to optically detect a single molecule were completed over two decades ago. Single-molecule spectroscopy has developed into a field that includes a wealth of experiments at room temperature and inside living cells. The fast growth of single-molecule biophysics ...
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Theory predicts that with a very short and very intense X-ray pulse, the image of a single diffraction pattern may be recorded from a large macromolecule, a virus, or a nanocluster of proteins without the need for a crystal. A three-dimensional data set can be assembled from such images when many copies of the molecule are exposed to the beam one by one in random orientations. We outline a meth...
متن کاملSingle Molecule Imaging
X-ray based methods are one of the premier tools for determining structure of a broad range of materials at the atomic level. Such information, including that on biological materials, has driven discovery and advances in many ways that range from gaining fundamental insights into structure-function relations to guiding the development of new materials based upon knowledge of structure. Diffract...
متن کاملSingle-molecule recognition imaging microscopy.
Atomic force microscopy is a powerful and widely used imaging technique that can visualize single molecules and follow processes at the single-molecule level both in air and in solution. For maximum usefulness in biological applications, atomic force microscopy needs to be able to identify specific types of molecules in an image, much as fluorescent tags do for optical microscopy. The results p...
متن کاملMolecular recognition imaging and force spectroscopy of single biomolecules.
In recent years, considerable attention has focused on biological applications of the atomic force microscope (AFM), in particular on high-resolution imaging of individual biological molecules and on the measurement of molecular forces under near-physiological conditions. The detection of intermolecular forces in the piconewton range has paved the way to investigate details on structural parame...
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ژورنال
عنوان ژورنال: The Review of Laser Engineering
سال: 2006
ISSN: 0387-0200,1349-6603
DOI: 10.2184/lsj.34.241